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|Section2= |Section3= }} 4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound used in the assessment of the efficacy of diets, drugs, and procedures in the prevention and treatment of cancer in animal models. It induces DNA lesions usually corrected by nucleotide excision repair. ==General== 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a heterocyclic aromatic structure and the same basic chemical formula of C9H7N.〔http://www.chemicalland21.com/industrialchem/organic/QUINOLINE.htm〕 4NQO may naturally occur in the environment but is typically manufactured for research purposes. 4NQO is known to mimic the biological effects of ultraviolet light on various organisms. Both 4NQO and its reduced metabolite 4-hydroxyaminoquinoline 1-oxide (4HAQO) bind covalently to cellular macromolecules such as nucleic acids and proteins. 4NQO may induce DNA damage through the production of reactive oxygen species thought to arise from enzymatic reduction of its nitro group, although its exact mechanism is unknown. 4NQO’s reactive oxygen species may serve as a byproduct of DNA damage or signaling molecule from damage. In response to damage from 4NQO, cells attempt to repair and initiate a transcriptional response to detoxify the cell from 4NQO and its metabolites. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「4-Nitroquinoline 1-oxide」の詳細全文を読む スポンサード リンク
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